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Dangers of Snorting, Smoking, or Injecting Meth

How does meth affect your life? > Safer ways to use

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Dangers of Snorting, Smoking, or Injecting Meth
Frum: https://americanaddictioncenters.org/meth-treatment/smoking-snorting-injecting

Frequent, ongoing intake of meth will eventually cause health problems, particularly if it’s smoked, snorted, or injected.

Snorting, predictably, can cause a lot of damage to the sinus cavity. People snort drugs because they can be absorbed through the sensitive mucus membranes in the nose. Over time, this causes the tissue to become dry and worn, resulting in chronic runny or bloody noses and sinus infections. Eventually, a hole can be worn in the septum.

According to the Office of National Drug Control Policy, smoking meth is the form of intake that is most likely to result in addiction. Any kind of smoking is hard on the mouth, throat, and lungs. Due to the fact that it’s made of such harsh chemicals, smoking meth tends to result in a condition referred to as meth mouth. Tooth decay and damage are common, including mouth sores and gum disease, the latter of which can lead to heart problems if left untreated.

Injecting drugs comes with its own unique risks. Needle sharing for drugs like meth is common and puts individuals at a high risk for contracting dangerous diseases like HIV and hepatitis C. Repeated use of needles also tends to cause general infections and collapsed veins. The meth particles in the solution can cause blockages in and near the heart, brain, and liver, causing serious health problems. The substance can also cause infection of the heart tissue, which is a very dangerous condition.

Following Frum: https://dancesafe.org/speed/

Injecting methamphetamine reaches the brain almost immediately, increasing the possibility of overdose…

Although rare, methamphetamine can cause seizures, heart attacks, strokes, and death from overdose.

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How does meth affect your life? > Safer ways to use

Methods of Use

Be aware of the risks of each method of use and take steps to reduce them:

Snorting: Snorting meth can lead to headaches and burns and sores on the interior membrane of the nose
Swallowing: Swallowing meth can cause damage to the teeth, throat and stomach lining.
Smoking meth can damage the teeth and lungs.
Injecting: Injecting meth can result in major damage to the body’s organs, inflamed and blocked blood vessels, abscesses and blood poisoning. Bacterial infections can occur, which may damage the heart valves, cause vein collapse, infection at injection site, bruising or more serious injuries if users inject into an artery or tissue.

Each type of drug using equipment has their unique set of risks, and sharing this equipment can increase the risk of being infected with things such as cold sores, or blood-borne viruses such as Hepatitis C or HIV.

Tips to reduce the risks

Try to use with a trusted person or group, so they can keep an eye out for you in case something goes wrong.
Some methods of use have a lower risk of blood borne virus transmission, snorting or swallowing your drugs can be a safer option.
If smoking meth, it is important to fully vaporise the meth. This will mean you are not inhaling liquid, which is harmful to your lungs. For this reason, consider using a jet lighter.
If injecting, use new injecting equipment every time and use correct swabbing and filtering techniques. If you do choose to re-use your equipment, make sure it is cleaned as best as you can.
Don’t share smoking or injecting equipment even if you know the person well. Even if you both have Hepatitis C, you may have different strains/genotypes, which could mean you get a new infection if you share equipment.


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NexT TexT Fruhm: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413312/
Pharmacologic Mechanisms Of…Meth]

Pharmacologic actions of methamphetamine…

In the brain, a primary action of methamphetamine is to elevate the levels of extracellular monoamine neurotransmitters (dopamine, serotonin, norepinephrine) by promoting their release from the nerve endings. We do not completely understand how methamphetamine causes neurotransmitter release, but it appears to involve redistribution of neurotransmitters from synaptic vesicles (via the vesicular monoamine transporter VMAT2) to the neuronal cytoplasm and the reverse transport of neurotransmitters through the plasma membrane transporter into the extracellular space.


NexT TexT Frum: [http://dmd.aspetjournals.org/content/45/7/770

Interaction and Transport of Methamphetamine and its Primary Metabolites]

Introduction

Following oral, inhalation, or intranasal administration, methamphetamine is well-absorbed into the bloodstream (Harris et al., 2003; Schep et al., 2010) and is distributed into many organs with the highest uptake occurring in lungs, liver, brain, and kidneys (Volkow et al., 2010).

Methamphetamine is eliminated by both hepatic [Liver] metabolism and renal [kidney] excretion.

In the liver, it is metabolized by the polymorphic enzyme cytochrome P450 2D6 to:


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Following TexT Frum: https://www.quora.com/Does-methamphetamine-break-down-into-phetamine-after-two-days-for-drug-test

Methamphetamine is double methylated phenylethylamine.

Methamphetamine actually breaks down and metabolizes into amphetamine.

Amphetamine is scientifically known as methylated phenylethylamine.

Methylation, the transfer of a methyl group (―CH3) to [ a chemical ] compound. Methyl groups may be transferred through addition reactions or substitution reactions; in either case, the methyl group takes the place of a hydrogen atom on the compound. Methylation can be divided into two basic types: chemical and biological.


Para-Hydroxymethamphetamine

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NexT TexT Fruhm https://www.revolvy.com/page/Pholedrine

Pholedrine (Paredrinol, Pulsotyl, Veritol), also known as 4-hydroxy-N-methylamphetamine (4-HMA), 4-hydroxymethamphetamine, and para-hydroxymethamphetamine,[1] is a drug that stimulates the sympathetic nervous system.

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NexT TexT Frum: [http://dmd.aspetjournals.org/content/45/7/770

Interaction and Transport of Methamphetamine and its Primary Metabolites]

Discussion

In summary, our study determined the molecular mechanisms involved in transport and disposition of methamphetamine and its metabolites. Moreover, our studies showed that methamphetamine has the potential to inhibit hOCT (human organic cation transporter) and hMATE (human multidrug and toxin extrusion) transporters at clinically relevant concentrations. Finally, we identified complex kinetic interactions between amphetamines and hOCT2 (human organic cation transporter). Our findings provide useful information that may be considered when prescribing medications to methamphetamine users to mitigate the risk of DDIs (drug-drug interaction)s that may potentially compromise therapeutic efficacy and drug safety.

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