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Endocannabinoids Paydj Frum: https://emedicine.medscape.com/article/1361971-overview

Humans and animals alike naturally synthesize endocannabinoids, chemical compounds that activate the same receptors as delta-9-tetrahydrocannabinol (THC), the active component of marijuana (Cannabis sativa)…

Endocannabinoids are crucial to bioregulation. Their main role is in cell-signaling, and, because they are hydrophobic, their main actions are limited to paracrine (cell-to-cell) or autocrine (same cell), rather than systemic, effects…

Research in animal models suggests the possible use of cannabinoids as anticancer drugs…

Multiple human and animal studies support that endocannabinoids play a key role in memory, mood, brain reward systems, drug addiction, and metabolic processes, such as lipolysis, glucose metabolism, and energy balance.

Potential therapeutic targets for cannabinoid pharmacologic intervention are as follows:

Pain

Antinausea

Cough

Glaucoma

Cachexia

Neurologic diseases: Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis, alcohol-induced neuroinflammation/neurodegeneration, traumatic brain injury, stroke, seizures

Autoimmune diseases: Autoimmune uveitis, systemic sclerosis, inflammatory bowel disease

Infection: HIV-1 brain infection

Psychiatric disorders: Anxiety-related disorders, impulsivity, bipolar disorder, personality disorders, attention-deficit/hyperactivity disorder, substance abuse and addictive disorders, anorexia nervosa

Cardiovascular: Atherosclerosis

Gastrointestinal: Gut motility disorders, inflammatory bowel syndrome, chronic liver diseases, alcoholic liver disease

Diabetic nephropathy

Osteoporosis

Cancer: Breast, prostate, skin, pancreatic, colon, and lymphatic, among others

The greater promise is that with this understanding, the ECS will yield an important therapeutic target for future pharmacologic therapy.


Endocannabinoid System Uhv Cannabinoid Uhv Kush Byb EL

TexT Below Frum: https://unitedpatientsgroup.com/blog/2016/02/09/the-endocannabinoid-system-UPG-cannabis-inside-the-body

"One interesting way that endocannabinoids differ from other neurotransmitters is that they transmit information in retrograde. This means that instead of traveling from the presynaptic neuron to the postsynaptic, they can flow the opposite way. In doing so, endocannabinoids can provide feedback to the nervous system. For example, endocannabinoids will travel “upstream” to inform presynaptic neurons when a neuron is firing too quickly…

"[W]hen THC connects with the endocannabinoid system, it provides highly effective pain relief. The THC modulates neurological function to reduce pain signals. Likewise, THC, when connected to the endocannabinoid system, can send malignant cells into apoptosis. The cellular process of autophagy is moderated by the endocannabinoid system. Autophagy not only keeps healthy cells alive, but also causes malignant cancer cells to consume themselves…

[C]annabinoids have antioxidant properties that neutralize free radicals that ultraviolet radiation generate. Free radicals are responsible for aging-related illnesses in humans, including cancer."